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The comorbidity between severe mental illness and substance use disorder is significant. Estimates indicate that approximately 25% of individuals with the most severe mental illnesses also have a substance use disorder. Conversely, about 10% of those seeking treatment for a substance use disorder are also diagnosed with a serious mental illness.

Prevalence of Comorbidity in Severe Mental Illness and Substance Use Disorder

A public health official is designing a screening protocol for a large healthcare system to efficiently identify individuals with co-occurring severe mental illness and substance use disorder. Based on established prevalence rates, which of the following assumptions should guide the protocol's design?

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