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Amphetamines exert their stimulant effects through a dual-action mechanism involving dopamine. They are similar to cocaine in that they block the reuptake of dopamine from the synapse, but they also actively stimulate the release of this neurotransmitter, which further increases its concentration and impact.

Amphetamine's Mechanism of Action

Amphetamines and cocaine are similar because both block dopamine reuptake, but amphetamines also stimulate dopamine release.

Comparison of Amphetamine and Cocaine Mechanisms of Action

A researcher observes that a certain stimulant drug causes a rapid and significant increase in the concentration of dopamine in the neuronal synapse. Which of the following descriptions of the drug's actions would best account for this observation?

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