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LSD is an agonist of 5-HT with high affinity for 5-HT2A and 5-HT2C and is small enough to pass the BBB being approximately 100 times more potent than psilocybin. Interestingly, LSD is also an agonist of the dopaminergic receptors with relatively high affinity for dopamine 2 receptors and an agonist of the trace amine associate receptor.

LSD (Lysergic Acid Diethylamide) Neurobiology

LSD effects the DMN in a remarkably
similar way to psilocybin. For instance,
LSD decreases within-network
connectivity (specifically the medialposterior DMN) and increases betweennetwork connections.


Modulation of DMN by LSD 

A researcher observes that a subject administered LSD experiences profound perceptual changes as well as effects on motivation and reward-seeking behavior. Which statement best dissects the neurobiological basis for this combination of effects?

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