The one variable found to have significant impact on the outcomes of iCBT was the level of adherence an individual had towards treatment. A higher level of engagement and interaction with the ICBT interventions directly predicted significantly better outcomes within the self-guided iCBT groups. 

Syracuse University

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Studies sought to test the moderating properties of demographic and clinical characteristics (baseline depressive symptom score) over depressive symptoms severity and treatment response. In addition to participant-level variables (sociodemographic and clinical characteristics) and study-level variables (type of comparator condition, recruitment, level of support, and treatment duration). Research has found no evidence that these variables significantly moderate the outcome of (iCBT). 

Possible mediators over internet-based cognitive behavioral therapy success

JAMA Psychiatry. 2017;74(4):351-359. doi:10.1001/jamapsychiatry.2017.0044

Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive Symptoms
A Meta-analysis of Individual Participant Data


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