While ketamine has been proven to decrease depressive symptoms in patients, the drug, like many others, has many harmful side effects. The most notable are potential addiction and withdrawal from overuse and dependence. Other notable side effects include but are not limited to: disassociation, hallucinations, hypertension, nausea, and headaches. Therefore, patients should consult a healthcare professional before starting any treatment plans.

Claremont McKenna College

Ketamine, a rapid-acting anesthetic and NMDA receptor antagonist, has been investigated for use in treatment-resistant  depression. When infused in sub-anesthetic doses over a short period (e.g. 40 minutes), ketamine has been shown to have rapid antidepressant effects that can last for up to 4 weeks in some patients.

Using ketamine for treatment-resistant depression

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