The data showed no clean correlation between the interferon score or genotype and age of patient. Eight patients who, at the time of sampling, were older than 20 years presented with a positive interferon score. The oldest patient was 32 years old and also presented with a positive interferon score. These results were interesting as age of onset of AGS is within 12 months of birth; however, the disease progresses early after onset of disease symptoms. There is not enough data to determine if an interferon signature can be related to severity of clinical phenotype.