Antiepileptic drugs can be used to effectively control many seizure disorders, including epilepsy. They work through two broad mechanisms: 1.) Addressing problems with ionic balance that cause increased excitability of neurons, and/or 2.) Promoting inhibitory processes. 

Brandeis University

Epilepsy

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Antiepileptic Drugs 

Starting in the 1940s, a small group of individuals had a procedure done where their corpus callosum was surgically split. This was done to provide relief from epileptic seizures that would start in one hemisphere and spread to the other. These procedures were very rare, with some only having partial splits. Because of this, only about 10 people have been fully studied.

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