There is evidence that neuroinflammation plays a role in the pathology of bipolar disorder, but further investigation is necessary to determine whether or not microglia are involved in this. However, microglia do appear to be overactive in the context of BD during both the manic and depressive phases, and they under-produce BDNF, which is involved in synaptic plasticity. There is some gene expression that differentiates the microglial function in BD patients and those with schizophrenia, as well as differences in postmortem microglia expression in BD patients who died by suicide versus those who did not, with the non-suicide group expressing lower levels of microglia density. Typical mood stabilizer treatments (lithium and valproic acid) seem to act on microglia, but the mechanism is unknown.

Microglia in Bipolar Disorder

Bipolar and Related Disorders, General is a topic of interest in Behavioral Neuroscience that includes connections and research related to:
- Microglia in Bipolar Disorder 


This includes the intersection of connections and/or research related to bipolar and related disorders as a general category in other fields of study and research. Such fields include:
- Behavioral Neuroscience
- Clinical Psychology
- Disability Studies
- Health Psychology
- Mindfulness

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Interdisciplinary Connections & Research Related to Bipolar and Related Disorders, General

Behavioral Neuroscience & Bipolar and Related Disorder, General

Bipolar and Related Disorder, in general, is a topic of interest in Clinical Psychology that includes connections and research related to:
- Sleep Disturbances in the Context of Neurohormal Dysregulation in Patients with Bipolar Disorders


Clinical Psychology & Bipolar and Related Disorders, General

Bipolar and Related Disorders, in general, is a topic of interest in Disability Studies that includes connections and research related to:
- Bipolar Disorder and Health Related Quality of Life
- Cognitive Functioning in Bipolar I and II Individuals Impact Learning Abilities 


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