Increased focus in this field would be useful to create virus-like NPs able to circulate in the blood system, overcoming the endothelial barrier, and to deliver their therapeutic payload with high efficiency.

Smith College

Nanomaterials could  be used to deliver drugs to the pulmonary system via inhalators. Cellular binding of viral particles at the alveoli can be inhibited using targeted nanoparticles (NPs) against angiotensin-converting enzyme 2 (ACE2) receptors or viral S protein. 

Nanomaterial-based Drug Delivery Systems for SARS-CoV-2

Weiss C, Carriere M, Fusco L, et al. Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic. ACS Nano. 2020;14(6):6383-6406. doi:10.1021/acsnano.0c03697

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

Biomimetic Engineering of Nanodelivery Systems

Airborne nanomaterials are optimally suited to penetrate into the deep lung (where alveolar epithelial type II cells (AECII) serve as a reservoir of the virus), due to the distinguished physicochemical properties of such aerosols. Nanomedicine is actively pursuing ideas to deliver drugs, therapeutic proteins, and mRNAs by exploiting nanodevices for pulmonary delivery.


Learn Before

Related