Dysfunction in frontolimbic systems are found in individuals with DPD. This has shown a relationship with hyperactivity in the fronto regions of the brain compared to non DPD controls.

Michigan State University

Sense of feeling detached from the body and environment. Individual feels as if they are an observer in their own body, as if thoughts and feelings aren't their own. Objects, people, and surroundings feel unnatural to them.

Depersonalization/ Derealization

Sierk, A., Daniels, J. K., Manthey, A., Kok, J. G., Leemans, A., Gaebler, M., Lamke, J.-P., Kruschwitz, J., &amp; Walter, H. (2018). White matter network alterations in patients with depersonalization/derealization disorder. Journal of Psychiatry and Neuroscience, 43(5), 347–357. https://doi.org/10.1503/jpn.170110 

White matter network alterations in patients with depersonalization/derealization disorder.

- Depersonalization: pronounced distinctions from the self
- Derealization: disconnections from external environment/reality

Depersonalization vs. Derealization

- Transient experiences (NOT depersonalization-derealization disorder)
- Long-term/enduring experiences (depersonalization-derealization disorder)

Depersonalization-Derealization Causes

- Physiological or emotional numbing
- Sensory impairments feelings of disembodiment
- Distorted experience of time
- Feeling as if one is in a dream
- Visual perceptual distortions
- An unreal/absent sense of self
- May hear voices (dissociative episodes; distinct from the auditory hallucinations experienced in psychosis)
- DON’T have psychosis and HAVE intact reality testing
- Symptoms often overlap with both anxiety and other dissociative disorders (PTSD or panic disorder, OCD, depression, schizophrenia)

Depersonalization-Derealization Disorder Symptoms

- Psychotherapy
- Supportive interventions
- Psychodynamic approach
- Pharmacotherapy

The most effective treatment for DDD is specifically adapted to address the complex traumas and high level of dissociation among DDD patients.

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