Caffeine acts by blocking the auto receptor effect of the endogenous ligand, adenosine. This in turn increase catecholamine release, resulting in arousal

Bowdoin College

One way drugs can effect presynaptic transmitter release is through modifying the systems that the neuron uses to monitor and regulate its own transmitter release. This includes altering the auto-receptor that monitors how much transmitter has been release presynaptically. 

Drugs altering transmitter release through modulation of presynaptic activity

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

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