Calcium channel blockers (ex: verapamil) block the influx of calcium that normally drives the release of transmitters into the synapse. They do so by blocking the calcium channels. 

Bowdoin College

Some drugs are able to alter synaptic transmitter release. This can be done through many ways but include the over stimulation and/or prevention of the release of transmitters. Some are even able to target specific transmitters. 

Drugs alteration of synaptic transmitter release

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Calcium channel blockers

The active ingredient in Botox, botulinum toxin, binds to specialized receptors in nicotinic cholinergic membranes and is transported into the cell, where it blocks calcium-dependent release of acetylcholine, resulting in muscle paralysis

Botulinum toxin

Amphetamines are a class of psychostimulant drugs that accelerate the transmission of messages between the brain and the body. While some forms are prescribed by doctors to treat conditions like Attention Deficit Hyperactivity Disorder (ADHD), they are also frequently produced and used illicitly, carrying a significant potential for abuse.

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