- Summary: This systematic review and meta-analysis is aimed at defining the clinical, electrocardiographic, and pathologic spectrum of cardiovascular disease (CVD), frequency of elevated cardiac and inflammatory biomarkers, and their frequency and relationship with severity of the disease and mortality in COVID-19 patients and to develop a triage risk stratification tool (TRST) that can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. Triage Risk Stratification Tool can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy.
- Method
- Result


Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool

- The study sought to assess COVID-19's impact on global cardiovascular diagnostic procedural volumes and safety practices.
- The International Atomic Energy Agency conducted a worldwide survey assessing alterations in cardiovascular procedure volumes and safety practices resulting from COVID-19. 
- Surveys were submitted from 909 inpatient and outpatient centers performing cardiac diagnostic procedures, in 108 countries. Procedure volumes decreased 42% from March 2019 to March 2020, and 64% from March 2019 to April 2020.  Location in a low-income and lower-middle-income country was associated with an additional 22% reduction in cardiac procedures and less availability of personal protective equipment and telehealth.
- COVID-19 was associated with a significant and abrupt reduction in cardiovascular diagnostic testing across the globe, especially affecting the world's economically challenged.


International Impact of COVID-19 on the Diagnosis of Heart Disease

- Hospitalizations for acute cardiovascular conditions have declined, raising concern that patients may be avoiding hospitals because of fear of contracting severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2).
- This investigation aimed to evaluate whether population-level deaths due to cardiovascular causes increased during the COVID-19 pandemic.
- The authors conducted an observational cohort study using data from the National Center for Health Statistics to evaluate the rate of deaths due to cardiovascular causes after the onset of the pandemic in the United States, from March 18, 2020, to June 2, 2020, relative to the period immediately preceding the pandemic (January 1, 2020 to March 17, 2020). Changes in deaths were compared with the same periods in the previous year.
- New York City experienced a large relative increase in deaths caused by ischemic heart disease (2.39, 95% confidence interval: 1.39 to 4.09) and hypertensive diseases (2.64, 95% confidence interval: 1.52 to 4.56) during the pandemic. 
- There was an increase in deaths caused by ischemic heart disease and hypertensive diseases in some regions of the United States during the initial phase of the COVID-19 pandemic. 

Cardiovascular Deaths During the COVID-19 Pandemic in the United States

Coronary Artery Disease (CAD) is the second most common form of cardiovascular disease in the United States, according to the American Heart Association. Apart from COVID-19, cardiovascular disease is the leading cause of death in the US, according to the Peterson-KFF Health System Tracker.

Coronary Artery Disease

Hypertension, commonly known as high blood pressure, is a significant cardiovascular disorder and a major risk factor for heart disease. This condition increases the physical strain on the heart by forcing it to pump blood more forcefully. A dangerous aspect of hypertension is that it often presents with no symptoms, leading to its description as the 'silent killer,' as individuals may be unaware they have the condition.

Hypertension

Cardiovascular disease is a risk factor for severe COVID-19, and COVID-19 causes cardiovascular complications. 

Cardiovascular Disease and COVID-19

Cardiovascular Disease Infographic | World Heart Federation

- According to the WHO, "Cardiovascular disease is the name for the group of disorders of heart and blood vessels."  
- As per WHO, cardiovascular disease includes hypertension, coronary heart disease, cerebrovascular disease,  peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease, and cardiomyopathies. 
- Cardiovascular disease is a risk factor for severe COVID-19, and COVID-19 causes cardiovascular complications. 

University of Michigan - Ann Arbor

Emory University

- As per NIH, chronic diseases usually last for ≥3 months and can be progressive.
- As per CDC, the deadliest chronic diseases in the US (from most to least deadly) are heart disease, cancer, CLRD, stroke, Alzheimer's disease, and diabetes.
- People with chronic diseases are more likely to experience severe complications of COVID-19 if they get infected.

Chronic Diseases

Luo, J., Zhu, X., Jian, J., Chen, X. U., & Yin, K. (2021). Cardiovascular disease in patients with COVID-19: evidence from cardiovascular pathology to treatment. Acta Biochimica et Biophysica Sinica, gmaa176. Advance online publication. https://doi.org/10.1093/abbs/gmaa176

Cardiovascular disease in patients with COVID-19: evidence from cardiovascular pathology to treatment

World Health Organization

- Cancer is a term that refers to a collection of diseases in which some of the body's cells divide uncontrollably and invade surrounding tissues. 
- Cancer can metastasize, i.e., spread to other parts of the body. Metastatic cancer is hard to treat and tends to be fatal. Most cancer deaths are caused by metastasis.

This node should be a relation node, but I can't delete it since it's a root node of the "cancer" tree and it has two upvotes.


Cancer

Cardiovascular disease 

Previous lung disease is a risk factor for mortality in patients with COVID-19. Older age, male gender, home oxygen therapy, and respiratory failure on admission were associated with an increased mortality. 

lung disease

- CKD, also known as chronic renal disease,  is a chronic, non-communicable, irreversible condition where kidney function gradually declines over time.
- However, CKD progression can be slowed down dramatically or even stopped.
- The earlier stages of CKD are usually asymptomatic.
- Diabetes and high blood pressure cause almost two-thirds of CKD cases.
- Source: https://www.kidney.org/atoz/content/about-chronic-kidney-disease

Chronic Kidney Disease

During the COVID-19 era the regular treatment and communication between physicians and patients regarding preexisting comorbidities has been disrupted. New guidelines and safety precautions must be put in place in order for physicians to still treat their patients and treat them through the use of telehealth or other means. While there are a lot of similarities between new communication policies being implemented across different areas of medicine, there are also many differences due to comorbidity specific criteria which facilitates different levels of involvement and communication between physicians and patients.


The comorbidities addressed under this node include:
- Cancer
- Cardiovascular Diseases
- Digestive Diseases
- Elective Surgeries
- Liver Diseases
- Psychological Disorders
- Renal Diseases

Changes to COVID-19 Patient Comorbidity Treatment and Communication

Diabetes is a collection of diseases in which blood glucose levels (i.e., blood sugar) is too high. The most common types of diabetes are type II diabetes, type I diabetes, gestational diabetes, and prediabetes.



Diabetes

- Alzheimer's disease is a progressive chronic disease. It's "a type of dementia that affects memory, thinking and behavior"; over time, these symptoms progressively interfere with daily tasks.
- It's the 6th leading cause of death. Current treatments can alleviate the symptoms but can't stop the progression of Alzheimer's.

Alzheimer's Disease

Neurodegenerative diseases refers to neurological diseases caused by neuronal death or deterioration due to many factors, including protein aggregation/misfolding, apoptosis, and mitochondrial dysfunction. 

Neurodegenerative Diseases

- Motivation
- Goal setting
- Problem Solving (overcoming barriers to positive change)
- Emotional Management
- Health Psychology

Link between Psychology and Chronic Diseases

Since mindfulness meditation can alleviate symptoms of distress, pain, and chronic disease, it can be used to treat hallucinations and delusions experienced by schizophrenic patients. 

What Symptoms Mindfulness Meditation can help Treat in Patients with Severe Schizophrenia

- Cystic fibrosis
- Diabetes
- Multiple sclerosis
- Cancers
- AIDS
- Hemophilia
- Epilepsy
- Hepatitis
- Hyperhidrosis
- Musculoskeletal Disorders
- Cardiovascular Diseases
- Long COVID

List of Medical Disabilities

Abnormally excessive sweating that is often unrelated to body temperature nor exercise. Known as the silent disorder, this is a widespread condition that affects almost 3% of the population. Currently, solutions to alleviate the condition either serve as temporary solutions or cause many other side effects.

Hyperhidrosis

"Chronic pain management" or "pain management" typically refers to the practice of employing pain killing medicines, psychological therapy/ practices, and/ or managing/ controlling the environment of the patient/ sufferer in order to lessen or mitigate the pain they feel or else make the pain in question more manageable.

Chronic Pain Management

Chronic pain is often a symptom of chronic conditions/ disabilities, though not always. In the medical sphere, "chronic pain" is defined as pain that may be constant in some sense of come and go. Or, in the case of conditions that may have a cure or may "heal", chronic pain is defined as pain that lasts longer than three to six months.

Chronic Pain

Chronic illness increases the likelihood of comorbid conditions such as mental illness and other physical conditions, a lower quality of life, increased cost of healthcare, and complications from a failure to manage the condition(s) properly. 

Learn Before

Related

Learn After