After a severe concussion, the former NFL player became one of the most extreme cases of retrograde amnesia. After the injury, Scott was unable to remember 46 years of his life.

Scott Bolzan

Kent Cochrane, known as patient K.C., was studied for years by Endel Tulving after a motorcycle accident caused a traumatic head injury and severe amnesia. K.C.'s case was remarkable for his complete episodic amnesia, meaning he was unable to recall any personal life events from his entire life, from birth to the present. However, his memory for experiences within the most recent one to two minutes remained functional.

Kent Cochrane (K.C.)

Phineas Gage, a 25-year-old railroad foreman in 1848, is one of the most renowned cases in neuroscience. He suffered a severe brain injury when an explosion drove a tamping iron through his face and skull, damaging his frontal lobe. Miraculously, Gage survived the accident, remaining conscious and able to walk and speak immediately after. However, in the following months, he underwent a profound personality transformation. Previously known as a well-mannered man, he began to exhibit strange and inappropriate behavior. This shift in personality is attributed to a loss of impulse control, a key function managed by the frontal lobe.

Phineas Gage

Henry Molaison (H.M.) is one of psychology's most famous case studies. In 1953, surgeons removed large sections of his hippocampus to treat severe epilepsy. While the surgery successfully stopped his seizures without affecting his IQ or personality, it left him with anterograde amnesia. His short-term memory remained intact, but he permanently lost the ability to transfer new information into long-term memory—a process known as consolidation. This case was crucial for memory research because it demonstrated a clear dissociation between short-term and long-term memory and highlighted the temporal lobes' essential role in memory consolidation.

Case of Henry Molaison (H.M.)

* Henry Molaison (H.M.)
* Kent Cochrane (K.C.)
* Scott Bolzan
* Phineas Gage

Columbia University

* Amnesia
* Dementia
* Alzheimer's Disease

Disorders of Memory

Spielman, R. M., Jenkins, W. J., & Lovett, M. D. (2020, April 22). Psychology (2nd ed.). OpenStax. https://openstax.org/books/psychology-2e/pages/1-introduction

OpenStax Psychology (2nd ed.) Textbook

Refers to memory deficits and loss, specifically the loss of long-term memory resulting from disease, physical injury, or psychological trauma. 

Amnesia

Alzheimer's disease is a specific type of dementia characterized as an irreversible, progressive brain disorder, which is understood to have a genetic basis. It gradually destroys memory and cognitive skills, eventually impairing the ability to perform simple tasks like walking, talking, and eating. This severe cognitive decline is associated with the formation of plaques in the brain resulting from cell death.

Alzheimer's Disease

According to the APA, dementia is a generalized, pervasive deterioration of memory and at least one other cognitive function, such as language and an executive function, due to a variety of causes. The loss of intellectual abilities is severe enough to interfere with an individual’s daily functioning and social and occupational activity.

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