 MIS-C is a rare but serious condition associated with COVID-19 that has been reported in children from Europe and North America. The clinical features of MIS-C may be similar to those of Kawasaki disease, Kawasaki disease shock syndrome, and toxic shock syndrome
-  They include persistent fever, hypotension, gastrointestinal symptoms, rash, myocarditis, and laboratory findings associated with increased inflammation; respiratory symptoms may be lacking

MIS-C in kids

multisystem inflammatory syndrome in children


Ohio State University, Columbus

-  The complete blood count was normal in most children; 17 percent had low white blood cell count and 13 percent had either neutropenia or lymphocytopenia; severe neutropenia has been described
-  Approximately one-third had elevated C-reactive protein (CRP; defined as >5 mg/L in most studies) or procalcitonin (defined as >0.5 ng/mL)
-  Elevated inflammatory markers and lymphocytopenia may indicate multisystem inflammatory syndrome in children (MIS-C)
-  Creatine kinase was elevated in 15 percent
-  Serum aminotransferases were elevated in 12 percent

Laboratory findings of children below 18 years of age

CDC and WHO case definitions of multisystem inflammatory syndrome in children. (n.d.). Retrieved August 14, 2020, from https://www.uptodate.com/contents/image?imageKey=PEDS%2F128201

CDC and WHO case definitions of multisystem inflammatory syndrome in children

CDC's and WHO's defination of MIS-C chart

Imaging findings are variable and may be present before symptoms. In a systematic review that included 674 children with confirmed COVID-19 infection who underwent imaging, approximately 50 percent had abnormalities.  Among 605 children who underwent computed tomography, 33 percent had normal findings, 29 percent had ground glass opacities, 27 percent had nonspecific unilateral findings, and 23 percent had bilateral findings.

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