Chloroquine and hydroxychloroquine are antimalarials that have been shown to be effective in targeting the coronavirus by inhibiting viral entry into the cells. However, the efficacy of these drugs was questionable and they are known to be extremely toxic. They are mainly metabolized by CYP3A4 and 2D6 so the suppression of 3A4 would push metabolism to 2D6 which is highly polymorphic. This means there are varying forms of the enzyme with different activities which could cause dangerous drug effects depending on the form the patient has.