Numerous clinical symptoms, encompassing a wide spectrum of organ systems, are associated with MIS-C. The clinical heterogeneity has made diagnoses difficult and misdiagnoses a frequent event. This review has compiled a list of clinical manifestations that a majority of MIS-C patients presented.

• Fever (922/928; 99.4%)
• Gastrointestinal symptoms (598/699; 85.6%)
• Abdominal pain (315/539; 58.4%)
• Vomiting (306/532; 57.5%)
• Diarrhea (268/532; 50.4%)
• Cardiovascular symptoms (307/387; 79.3%)
• Tachycardia (194/253: 76.7%)
• Hypotension (416/695; 59.9%)
• Myocarditis (128/309; 41.4%)
• Pericardial Effusion (114/511; 22.3%)
• Respiratory Symptoms (295/587; 50.3%)
• Upper respiratory tract symptoms (95/397; 23.9%)
• Dyspnea (101/378; 26.7%)