Il-beta induces fevers through the changes in vascular permeability which leads to localized inflammation. 


Tulane University

- Clinical phenotype
- Molecular phenotype
- Function
- Treatment for signaling dysregulation

Interleukin-1 Beta (IL-B)

Parham, P. (2009). Vaccination to Prevent Infectious Disease. In 1145902806 862124677 J. Foltin (Ed.), The Immune System (3rd ed., pp. 62-65). New York, New York: Garland Science, Taylor & Francis Group.

The Immune System

Clinical Phenotype of IL-B

This cytokine is very potent and acts as a transcription factor to express inflammatory genes. It induces the differentiation of the myeloid progenitor to produce more cells of the innate immune system, while continuously fighting against the pathogen. 

Molecular Phenotype of IL-B

Interleukin-1 beta is regulated by an IL-1 receptor antagonist (IL-1 Ra), inhibiting the signal transduction pathway. Anakinra is a recombinant form of IL-1 Ra and commonly used to treat patients with IL-1 signaling disorders. 
Monoclonal antibodies that bind to IL-1Beta in the blood block the cytokine from binding to IL-1 receptors, deactivating that pathway. An example of this treatment is canakinumab. 

Treatment Approaches

A primary function of IL-B is to attract natural killer cells and raise body temperatures to deter the replication of pathogens. 


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