ClinicalTrials.gov. (2024). Efficacy and safety of gemlapodect (NOE-105) in adults and adolescents with Tourette syndrome (Identifier NCT06315751). U.S. National Library of Medicine. https://clinicaltrials.gov/study/NCT06315751
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Gilbert, D. L., Murphy, T. K., Jankovic, J., Budman, C. L., Black, K. J., Kurlan, R. M., Coffman, K. A., McCracken, J. T., Juncos, J., Grant, J. E., & Chipkin, R. E. (2018). Ecopipam, a D1 receptor antagonist, for treatment of tourette syndrome in children: A randomized, placebo-controlled crossover study. Movement disorders : official journal of the Movement Disorder Society, 33(8), 1272–1280. https://doi.org/10.1002/mds.27457
Darwish MK, Nasser M, Mohammed HE, et al. Is Ecopipam an effective treatment for Tourette syndrome? A systematic review and meta-analysis with GRADE assessment. Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2026;62:2. DOI: 10.1186/s41983-025-01064-2
Panda, P. K., Panda, P., Dawman, L., Mishra, A. S., Kumar, V., & Sharawat, I. K. (2025). Safety and Efficacy of Ecopipam in Patients with Tourette Syndrome: A Systematic Review and Meta-analysis. CNS drugs, 39(2), 127–142. https://doi.org/10.1007/s40263-024-01140-w
ClinicalTrials.gov. (2024). Efficacy and safety of gemlapodect (NOE-105) in adults and adolescents with Tourette syndrome (Identifier NCT06315751). U.S. National Library of Medicine. https://clinicaltrials.gov/study/NCT06315751
Noema Pharma AG. (2024a, October 17). Noema Pharma announces NOE-105 (gemlapodect) Phase 2a study in Tourette syndrome met primary and all key secondary endpoints. https://noemapharma.com/2024/10/17/noema-pharma-announces-noe-105-gemlapodect-phase-2a-study-in-tourette-syndrome-met-primary-and-all-key-secondary-endpoints/
Noema Pharma AG. (2024b, October 30). Noema Pharma announces first patients dosed in Phase 2b study with gemlapodect (NOE-105), a first-in-class investigational therapy for Tourette syndrome. https://noemapharma.com/2024/10/30/noema-pharma-announces-first-patients-dosed-in-phase-2b-study-with-gemlapodect-noe-105-a-first-in-class-investigational-therapy-for-tourette-syndrome/
Besag, F. M., Vasey, M. J., Lao, K. S., Chowdhury, U., & Stern, J. S. (2021). Pharmacological treatment for Tourette syndrome in children and adults: What is the quality of the evidence? A systematic review. Journal of psychopharmacology (Oxford, England), 35(9), 1037–1061. https://doi.org/10.1177/02698811211032445