- less than 10% of the cells coexpress TMPRSS2 and ACE2
- coexpression primarily in type II pneumocytes and ciliated cells of the lungs
- coexpression also observed in the absorptive enterocytes in the ileum

State University of New York at Stony Brook

Coexpression of TMPRSS2 and ACE2

Xiao, L., Sakagami, H., & Miwa, N. (2020). ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?. Viruses, 12(5), 491.
doi: 10.3390/v12050491

ACE2: The Key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

Ziegler, C. G., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., ... & Feldman, J. (2020). SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell.
https://doi.org/10.1016/j.cell.2020.04.035

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