One of the common adducts that are formed on the P53 is the O6-methylguanine adduct which causes G->A transitions. Additionally, these mutations are frequently observed on the KRAS oncogene and P53 for lung cancers. These damages are caused by PAHs.

State University of New York at Stony Brook

P53 mutations do not occur randomly but have certain mutation hotspots. These hotspots are within a domain of about 180 amino acids from codon 120 to 130. These are specifically G-to-T transversions in lung cancer, brain, breast, and colorectal cancers. The hotspot locations are important because they can allow the specific assignment of particular carcinogens to that mutated site. These specific sites can also be linked to specific cancers.  


p53 Mutations

Centers for Disease Control and Prevention (US). “How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease.” National Center for Biotechnology Information, U.S. National Library of Medicine, 1 Jan. 1970, www.ncbi.nlm.nih.gov/books/NBK53017/.


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