Mood dysphoria, cognitive problems, and neurotransmitter depletion can lead people to compulsively use stimulants such as cocaine and amphetamines, in part to try to reestablish the person's physical and psychological pre-use baseline.

Compulsive Stimulant Use

The depletion of certain neurotransmitters from repeated stimulant use can lead to mood dysphoria, cognitive problems, and other factors.

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Repeated use of stimulants alters normal brain functioning. It can lead to an overall depletion among the monoamine neurotransmitters (dopamine, norepinephrine, and serotonin).

Brain Function Alteration from Repeated Stimulant Use

Spielman, R. M., Jenkins, W. J., & Lovett, M. D. (2020, April 22). Psychology (2nd ed.). OpenStax. https://openstax.org/books/psychology-2e/pages/1-introduction

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