Although this medication has been reported to make a huge difference for those with PMDD it is immensely expensive, costing around $2,000 or more per injection, and insurance often does not cover it. 

New York University

If any of the less invasive treatments for PMDD fail, doctors may recommend taking leuprolide acetate, an injectable medication normally used to treat endometriosis. This medication can be given once a month or every three months so that the ovaries stop producing estrogen and progesterone. This can eliminate monthly symptoms. 

Injectable Medications for PMDD

Peachman, R. R. (2022, September 20). Do antidepressants work for severe PMS? The New York Times. Retrieved October 14, 2022, from https://www.nytimes.com/2022/09/20/well/live/antidepressants-pms-treatment.html 

Do Antidepressants Work for Severe PMS?

Although this medication is supposed to be very helpful it does come with a number of side-effects such as headache, fever, and muscle aches. 

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