For the most part, drug metabolism functions to inactivate medications while few drugs are actually activated during the process. CYP enzymes are mainly found in the liver and are responsible for a large amount of drug metabolism. In fact, CYP3A4 is responsible for over 60% of drug metabolism. During viral infection the release of inflammatory proteins and suppress CYP enzymes. Although the effect of SAR-CoV-2 on CYP enzymes has not been fully studied, based on data collected from other viral infections and inflammatory diseases on CYP regulations there is a general downregulation of the enzymes especially with CYP3A4. This is seen with an increase in individual inflammatory markers. The effect of multiple cytokines at once, as seen in a cytokine storm, is unknown but assumed to be additive or synergistic.