To convert a Pandas DataFrame into a Bokeh ColumnDataSource, pass the DataFrame as an argument to the ColumnDataSource constructor:

import numpy as np
import pandas as pd
from bokeh.models import ColumnDataSource

# Create a sample Pandas DataFrame
df = pd.DataFrame(
    np.array([
        [33.9, 4, 65, 'US'],
        [32.4, 4, 66, 'Asia'],
        [21.4, 4, 109, 'Europe']
    ]),
    columns=['mpg', 'cyl', 'hp', 'origin'],
    index=['Toyota', 'Fiat', 'Volvo']
)

# Convert the DataFrame to Bokeh ColumnDataSource
cds_df = ColumnDataSource(df)