Concept

28-day mortality results in a randomized controlled trial of Dexamethasone (DEX) among hospitalized COVID-19 patients in the UK RECOVERY project

  • Among patients receiving mechanical ventilation: DEX group mortality rate was 29.0% compared to 40.7% in control group (RR 0.65, 95% CI: (0.51, 0.82), p<0.0001)

  • Among patients with other supplemental oxygen: DEX group mortality rate was 21.5% compared to 25% in control group (RR 0.80, 95% CI: (0.70, 0.92), p=0.002)

  • Among patients without any supplemental oxygen: DEX group mortality rate was 17.0% compared to 13.2% in control group (RR 1.22, 95% CI (0.93, 1.61), p=0.14)

  • Within the standard care group, 28-day mortality was highest for those on ventilation at randomization (40.7%), intermediate for oxygen only (25.0%), and lowest for no oxygen *13.2%)

  • A test for trend determined that DEX use significantly reduced mortality for longer illnesses

  • See table 2 node for more detail

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Updated 2020-06-26

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences