Gattuso, J. J., Perkins, D., Ruffell, S., Lawrence, A. J., Hoyer, D., Jacobson, L. H., Timmermann, C., Castle, D., Rossell, S. L., Downey, L. A., Pagni, B. A., Galvão-Coelho, N. L., Nutt, D., &amp; Sarris, J. (2022). Default mode network modulation by psychedelics: A systematic review. International Journal of Neuropsychopharmacology, 26(3), 155–188. https://doi.org/10.1093/ijnp/pyac074 

Alma College

Default Mode Network modulation has been a consistent approach to understanding the effects and mechanisms of different psychedelic drugs. It is a current hypothesis that the relation of DMN modulation has a relation with the therapeutic effects of these drugs. Nonetheless, the mechanisms of this relation are still unclear.  

DMN modulation by use of psychedelics 

Every psychedelic drug has its own mechanism of interaction with the Default Mode Network. Nevertheless, acute disruption in resting-state connectivity and increased functional connectivity between canonical resting-state networks seems to be a consistent finding in regard to modulation. 


Modulation of DMN

Default Mode Network Modulation by Psychedelics: A
Systematic Review

Currently, DMN modulation in terms of therapeutic effects is a theory and causality is hard to address in terms of internal validity. Furthermore, there are still discrepancies in the psychedelic mechanism of action which can obscure the origin of the therapeutic effects.

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