- Tonic Dopamine effects stabilizes the maintained representations. Phasic dopamine effects serve as gating signals - informing when new information should be encoded or when old information should be upgraded 

New York University

- Dopamine concentration highest in the PFC - D2 receptors layer V. Mesocortical dopaminergic system anatomical distribution suggest it influences anterior brain structures 
- Depletion of dopamine or blockage of dopamine receptor impairs working memory tasks performed by monkeys NOT observed when other neurotransmitters are depleted (seratonin, norepinephrine)
- Evidence from Parkinson's disease patients
- Administration of dopamine receptor agonists &/or antagonist to healthy young adults. Effecting working memory but not other cognitive abilities 

Dopamine & Working Memory 

D'esposito, Mark. (2008). Working Memory. Handbook of Clinical Neurology. Vol. 88.

Working Memory

- Interacting with capacity of working memory. Subjects with lower baseline capacity for working memory improved no the dopamine receptor agonist drug. Whereas subjects with a higher baseline capacity for working memory were impaired on the drug.
- Dose response curve - optimal response

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