Testing development is limited. manual assays requires careful quality control.

University of California, Santa Cruz

Serial Dilutions of patient convalescent serum are added to known strains of the virus. The mixture is mixed into a a susceptible cell mono-layer and incubated for virus adsorption. Viral infection can be measured by microscope, 5-day incubation, or fluorescence.

Dcruz, R. J., Currier, A. W., & Sampson, V. B. (2020). Laboratory Testing Methods for Novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Frontiers in Cell and Developmental Biology, 8. doi:10.3389/fcell.2020.00468

Frontiers in Cell and Developmental Biology

Disadvantages of SVN

Produces reproducible tests to identify the best candidate for treatment. The neutralizing activities along with the viral load and antibody titres can all be monitored in plasma samples to predict clinical efficacy.
Testing is also inexpensive.

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