- Factors that affect the relationship between a drug and its receptors/targets 
- Examples include binding affinity and intrinsic activity

Pharmacodynamics 

- A plot of the drug's effect versus the dose 
- Used to assess important drug characteristics 
- One of the main tools for understanding pharmacodynamics 

Rutgers University

- Greater drug doses tend to produce greater effects
- This relationship is shown in dose-response curves

Dose Response Relationship 

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Dose Response Curve 

As a result of drug tolerance, some users of amphetamine would take large doses to experience a "high". From this, these users would develop symptoms of paranoia (auditory hallucinations, bizarre motor behavior, etc), which closely resembled schizophrenic symptoms.

Not only that, but amphetamine worsens symptoms of schizophrenia. Amphetamine is found to promote the release of dopamine and prolong the action of the released transmitter by blocking reuptake.

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