Curare blocks the nicotinic ACh (acetylcholine) receptors found on muscles, resulting in immediate paralysis of all skeletal muscles, including those used for breathing.

Curare

Drugs can impact the postsynaptic cell by binding directly to the postsynaptic receptors and acting as a blockade, preventing them from being activated by their neurotransmitter.

Bowdoin College

Drugs can effects post synaptic events by directly effecting transmitter receptors. This can occur through:
- blockade of receptors
- activation of receptors

Drugs effects postsynaptically on transmitter receptors 

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Drugs effect of blocking receptors postsynaptically

Drugs such as selective receptor agonists bind to specific receptors and activate them, mimicking the natural neurotransmitter at those receptors. these drugs are often very potent, with effects that vary depending on the particular types of receptors activated.

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