- First-generation antipsychotics (chlorpromazine and haloperidol)
- Drugs with dopamine-antagonist activity (metoclopramide)
- Abrupt discontinuation of dopamine agonists (levodopa)

Rutgers University

A drug-induced neurologic disorder caused by neuroleptic and antipsychotic drugs. Thought to result from dopamine receptor D2 blockade in the corpus striatum, spinal cord, and hypothalamus. Once begun, symptoms progress rapidly and reach peak severity at 72 hours. 

Neuroleptic Malignant Syndrome

Lane RJ, Routledge PA. Drug-induced neurological disorders. Drugs. 1983;26(2):124-147. doi:10.2165/00003495-198326020-00002



Drug-Induced Neurologic Conditions

Drugs that induce neuroleptic malignant syndrome

- Muscular rigidity
- Autonomic instability
- Fever
- Changes in cognition (e.g., delirium)

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