- Antidepressants (SSRI and SNRI)
- Opiate analgesics (Demerol)
- Migraine drugs

Rutgers University

Serotonin Syndrome (SS) include predictable symptoms resulting from excess serotonin  and overstimulation of 5-HT receptors. SS can range from mild to severe and is potentially fatal, although its incidence is low.  SS rarely occurs with use of a single agent; it is more commonly the result of a drug-drug interaction. 

Serotonin Syndrome

Lane RJ, Routledge PA. Drug-induced neurological disorders. Drugs. 1983;26(2):124-147. doi:10.2165/00003495-198326020-00002



Drug-Induced Neurologic Conditions

Drugs that induce serotonin syndrome:

- Cognitive and behavioral changes
- Neuromuscular excitability
- Autonomic instability
- Sweating
- Agitation
- Tremor
- Fever
- Nausea and vomiting

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