The Circadian clock is known to control the function of our immune systems, replication of viruses and infection severity. Humans are more prone to getting infected at specific times of the day, since our bodies follow a rhythmic pattern daily. Disruption of our circadian clock can lead to rapid virus replication which can cause severe form of infection. The time of day when vaccinated can influence the the antibody response generated in our bodies. Circadian rhythms should be taken into consideration when designing and dosing potential drug/vaccinations against SARS-CoV-2 to ensure better outcomes. Surprisingly, many of the physiological processes negatively impacted by SARS-CoV-2 are regulated by the circadian clock.