It was found that Ayahuasca worked best as an antidepressant when treating mild to moderate depression symptoms.

Syracuse University

- Depression scores (BDI and DASS-21 scores) after Ayahuasca use.
- Length of antidepressant effects after Ayahuasca use.
- Effectiveness of Ayahuasca on different depression levels.




Depression Levels and Ayahuasca Use

Van oorsouw, K., Toennes, S. W., & Ramaekers, J. G. (2022). Therapeutic effect of an ayahuasca analogue in clinically depressed patients: A longitudinal observational study. Psychopharmacology, 239(6), 1839-1852. https://doi.org/10.1007/s00213-021-06046-9

Therapeutic effect of an ayahuasca analogue in clinically depressed patients: A longitudinal observational study

Depression scores (BDI and DASS-21 scores) decreased significantly as time went on since prior to treatment 71% of participants has high levels of depression and 17% had mild levels. One month after treatment 68% of participants had higher depression scores and 47% had low scores, a year after treatment 65% of the participants had their scores decrease by 50% or more.

Depression scores after Ayahuasca Use

After one dose, ayahuasca can cause antidepressant effects for up to a year after being used.

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