Phillips, T. (2008) The role of methylation in gene expression. Nature Education, 1(1), 116. https://www.nature.com/scitable/topicpage/the-role-of-methylation-in-gene-expression-1070/

The role of methylation in gene expression

Jang, H. S., Shin, W. J., Lee, J. E., & Do, J. T. (2017). CpG and non-CpG methylation in epigenetic gene regulation and brain function. Genes, 8(6), 148. https://doi.org/10.3390/genes8060148

CpG and non-CpG methylation in epigenetic gene regulation and brain function

University of Minnesota - Twin Cities

Epigenetics involves genetic control by factors other than an individual's DNA sequence. Epigenetic changes can switch genes on or off and determine which proteins are transcribed. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence.

Epigenetic Influence

DNA methylation is a common epigenetic signaling tool that cells use to regulate gene expression. It occurs by adding or removing a methyl group at the fifth carbon of the pyrimidine ring of cytosine to form 5-methylcytosine (5mC). Given the nature of this mechanism—wherein it can have a significant effect on cell development and differentiation—errors in methylation could give rise to a number of devastating consequences, including various diseases.

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