1Cademy - Exercise and epigenetics

Relation

Exercise and epigenetics

Exercise can promote brain remodeling through epigenetic effects (reversible changes in gene expression without altering DNA base pairs).
Histone modification - a form of gene transcription regulation - after exercise often occurs through activation of HAT and inactivation of HDAC, which is shown to increase cognitive function and memory formation in rats.
DNA methylation is influenced by exercise and can lead to improved cognitive function, upregulation of BDNF, downregulate the p75 receptor linked to cell death.
Chromatin remodeling also occurs at the Bdnf gene to increase BDNF production.
Changes in the prevalence of certain microRNAs take place to promote cognition and neurogenesis.