It is worth noting that feelings of worthlessness emerged as an additional symptom in the network of self-reported depressive symptoms among participants with—but not without—a history of any childhood trauma. The experience of shame—which can manifest as a sense of inadequacy or worthlessness—can have a debilitating consequence of childhood trauma. If this study/results are replicated, it would imply that patients with BD who report a history of childhood trauma may especially benefit from psychological treatments that target feelings of worthlessness.