As can be seen from the figure, Vitamin D prevents functioning of pro-inflammatory receptors. Also, the Renin-Angiotensin system is suppressed, preventing overproduction of Angiotensin to. As a result, this prevents inflammation. When cathelicidin presence increases due to vitamin D, the cytokines storm can be avoided, thus preventing multi organ failure.

Michigan State University

- Vitamin D lowers Th1 production, preventing inflammation by reducing the presence of cytokines (IL-6, IL-8, etc.)
- Inhibiting production of cytokines can aid in avoidance of the cytokine storm, thus make organ damage less likely to occur
- When vitamin D is active, there is an increased expression of cathelicidin
- Cathelicidins can help prevent lung damage when too much oxygen is present in the lungs
- Cathelicidins could be used as a protective agent against COVID-19, as it prevents the virus from replication, thus reducing their chances of survival
- Vitamin D prevents the production of renin, which is necessary for producing Angiotensin II. As a result, Vitamin D can be used in those with high levels of Ang II to decrease inflammation.


Vitamin D Physiological Impact

Aygun, H. (2020). Vitamin D can prevent COVID-19 infection-induced multiple organ damage. Naunyn-schmiedeberg's Archives of Pharmacology, 1-4.

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