 Flow diagram of individual selection and allocation

University of Michigan - Ann Arbor

- Day 3: no difference in reduction in viral load between intervention and control arms (difference of 0.01, [95% CI 0.28, 0.29])
- Day 7: no difference in reduction of viral load between intervention and control arms (difference of -0.07, [95% CI -.44, .29])
- No reduction in risk of hospitalization: 7.1% in control versus 5.9% intervention (RR .75, [95% CI .32, 1.77])
- No shortened duration of symptoms: 12 days in control versus 10 in intervention (log rank test for survival analysis p=0.38)

Results from Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial

Mitjà,O., Corbacho-Monné, M., Ubals,M. et al. Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial, Clinical Infectious Diseases, , ciaa1009, https://doi.org/10.1093/cid/ciaa1009

Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial

- Mean age: 41.6 years
- 68.6% women
- 86.7% were healthcare workers
- Mean baseline viral load: 7.90 (SD 1.82) Log$_{10}$ copies/ mL
- Median time from symptom onset to enrollment: 3 days

(The two study arms had comparable demographics including age, gender, comorbidity, symptoms, and nasopharyngeal viral load)

Demographics from Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial

Figure 1

Change from baseline in SARS-CoV-2 viral RNA on nasopharyngeal swabs (intention-to-treat)

Box plot of viral load of participants in the control arm (blue box) and the intervention arm (red box) at each assessment point (x-axis), determined by quantitative RT-PCR. Boxes represent median and IQR for each group, outliers are plotted as individual points. The number of samples tested are as follows: day 1, 293; day 3, 271; day 7, 211.

Figure 2

Time to clinical improvement from randomization (intent-to-treat).

Survival curve of participants in the control arm (blue line, median [IQR] 12.0 [6.0-21.0]) and in the intervention arm (red line, median 10.0 [4.0-18.0], log rank test (p= 0.38)).

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