Many hypotheses of the detrimental effects of RAS inhibitors have been proposed although more research needs to be conducted on more substantial studies of the harmful effects

State University of New York at Stony Brook

Some believe that ACE-I/ARB use is harmful in treating SARS-CoV-2 infections because they increase the expression of ACE2, allowing the virus more opportunity to enter host cells.  

"Harmful" ACE-I/ARB Hypothesis in Treating SARS-CoV-2 Infection

Shukla, A.K., Banerjee, M. Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update. High Blood Press Cardiovasc Prev (2021). https://doi.org/10.1007/s40292-021-00439-9

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