- GC376 forms a covalent bond with the active site residue Cys145, and can directly block activity of the main protease, which plays a key role of viral infection in the host cell. It was found that GC376 was stabilized in the active site of the main protease of SARS-CoV-2 by multiple hydrophobic and hydrophilic interactions.

Santa Clara University

- The Kd value of GC376 to the main protease of SARS-CoV-2 is 1.6uM. This value was determined by isothermal titration calorimetry.

Binding affinity of GC376 to SARS-CoV-2

Wang, Y., Yang W., Chen Y. et al.(2020 Aug 1). Structural basis of SARS-CoV-2 main protease inhibition by a broad spectrum anti-coronaviral drug. American Journal of Cancer Research, 10(8): 2535-2545. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471349/pdf/ajcr0010-2535.pdf	


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