- Increased expression of this receptor in bronchoalveolar lavage myeloid cells decreased neutrophilic inflammation in the lungs (associated with WBCs)
- ARDS patients in randomized trials were should to have increase functioning of the GC-GRα receptors with methylprednisolone
   - Decreased functioning of inflammatory, coagulative, and fibroproliferation markers (includes systemic and pulmonary nuclear factor- κB-activated markers)
     - These markers are known to induce the pathogenesis of COVID-19 when functioning is not impaired


Michigan State University

Corticosteroid therapy involves the activated glucocorticoid receptor α

GC-GRα

Arabi, Y. M., Chrousos, G. P., & Meduri, G. U. (2020). The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19.

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