Similar to SARS-CoV-2, influenza A virus (H5N1) is a viral respiratory disease that affects the lungs. Glycyrrhizin can reduce H5N1’s ability to affect IL-6 and chemokine production, and it also blocked DNA binding of the virus. For this reason, glycyrrrhizin could be a very powerful antiviral agent that should be considered for the prevention of SARS-CoV-2 infection.