Granuloma Figure (Figure 17.24). Reprinted from OpenStax Microbiology (p. 715), by N. Parker, M. Shneegurt, A.-h. Thi Tu, B. M. Forester, and P. Lister, 2016, Rice University. Copyright 2016 by Rice University.

Parker et al. 2016: Granuloma Figure

Pocket of infected tissue surrounded by white blood cells in which phagocytes failed to eliminate pathogens and dead tissue. (Signals failed immune response)

(Photo credits in References)

University of Notre Dame

When acute inflammation fails to rid a pathogen, this kicks in, resulting in ongoing inflammation and an often futile defense (healing at superficial level but pathogen in deeper tissues). This may cause the formation of granulomas, which is a marker for unsuccessful immune response in tissues.Chronic inflammation can also be the cause of tissue damage during viral infections (i.e. HepC, liver cirrhosis). 

Chronic Inflammation

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