Concept

Histopathologic Scoring

Pulmonary pathology, a measurement of the severity of ARDs, was scored using random forest tissue segmentation algorithms. These algorithms recognized fibrin, edema and cellular inflammation using HALO software. Tissues samples from each of the right lung lobes were analyzed to determine the percentage of inflamed tissue. The percentage of inflammation was converted to a pathology score based on the following scoring system: fibrin and edema score of 0, 0% to 2%; 1, 2% to 5%; 2, 5% to 15%; 3, 15% to 30%; and 4, >30%; and cellular inflammation score of 0, 0% to 0.5%; 1, 0.5% to 3%; 2, 3% to 6%; 3, 6% to 12%; and 4, >12%.

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Updated 2021-02-21

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences