Drew, E.D., Janes, R.W. Identification of a druggable binding pocket in the spike protein reveals a key site for existing drugs potentially capable of combating Covid-19 infectivity. BMC Mol and Cell Biol 21, 49 (2020). https://doi.org/10.1186/s12860-020-00294-x

Kenyon College

California Polytechnic State University, San Luis Obispo

At least 100 existing pharmaceuticals can theoretically bind to COVID-19's spike protein and hinder or slow the infection process. These include Irolapride, an antidepressant, and Pirifibrate, an antilipidemic. 
These existing drugs are valuable, as they are both readily available and may already be cleared for use in humans. Their effectiveness otherwise remains unknown. 

Using Existing Pharmaceuticals to Target Binding Pockets

Identification of a druggable binding pocket in the spike protein reveals a key site for existing drugs potentially capable of combating Covid-19 infectivity

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