The general malaise, tiredness, fever and social withdrawal are caused by activation of specialized immune cells in the brain, called neuroimmune cells, and signals in the brain. Neuroimmune cells sit at synapses and provide energy by minute to the brain by releasing inflammatory signals which are essential for normal memory signaling. Unfortunately the virus can cause acute neurological symptoms and long-lasting impacts to the brain. The virus requires alot of neuroinflammatory signaling. Many neurological connections are destroyed and connections at gap junctions are destroyed which are needed to store memory.