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Impact of Tamoxifen from a Chemotherapy Drug to an Antiviral Drug to Treat COVID-19 Patients
- Tamoxifen is used to treat breast cancer patients
- Tamoxifen (TAM) makes sure that bone density stays within the normal range in postmenopausal women
- TAM also decreases the risk damage caused by cardiovascular disease
- TAM binds to estrogen
- TAM suppresses viral replication
- NK cells were deficient in those with severe SARS coronavirus (two decades ago)
- NK cells aid in immunity against pathogens
- 10-20% of lymphocytes are NK cells found in the lungs
- TAM regulates the activity of NK cells, and other white blood cells
- TAM reduces PGE2 activity, increasing NK cell activity
- Reduction in PGE2 reduces viral replication
- TAM increases Nrf2 activity in breast cancer patients
- TAM prevents HIV replication when PKC is increasing viral replication
- TAM functioning increases if given before the onset of an infection
- TAM target viruses with spikes present on them (along with envelopes)
- TAM may be more beneficial than chloroquine in patients with COVID-19
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Updated 2020-08-17
Tags
SARS-CoV-2 (COVID-19)
Biomedical Sciences