1Cademy - Interaction Between Tissue Expression of ACE2 Receptors and SARS-CoV-2 Circulation.<br>

Concept

Interaction Between Tissue Expression of ACE2 Receptors and SARS-CoV-2 Circulation.

The presence of the COVID-19 virus in the general circulation understandably enables it to pass into the cerebral circulation (Figure 1A−C)
Movement of the blood within the microcirculation could be one of the factors that may facilitate the interaction of the COVID-19 virus spike protein with ACE2 expressed in the capillary endothelium.
The budding of the viral particles from the capillary endothelium and damage to the endothelial lining can favor viral access to the brain (Figure 1B)